Dissolution Rate Of Ibuprofen Pills


The purpose of this experiment was to determine the rate of dissolution for different brands of Ibuprofen. 

I became interested in this idea when I had a headache and took an Advil and I decided that it would be a good idea to see which brand would cure my headache the fastest.

The information gained from this experiment could benefit every person that has had a headache and didn’t get the fastest relief possible. I think that everyone has the need to get his or her headaches relieved as soon as possible.

Dissolution Rate Of Ibuprofen Pills


My hypothesis was that the roughest and smallest pill would dissolve the quickest.

I based my hypothesis on the fact that the smallest and roughest pill would break up the quickest because it isn’t as well compacted as the others.


The constants in this study were:
  •  Amount of water (250ml) for each test
  •  Temperature of water (37∞ Celsius)
  •  Speed of magnetic stirrer (high setting)
  •  Type of water (tap)
  •  Amount of pills (one) tested at one time
  •  Testing procedures
  •  Type of stopwatch 
  •  Type of pill (Ibuprofen)
The manipulated variable was the brand of Ibuprofen.

The responding variable was the dissolution time. 

To measure the responding variable I used a stopwatch accurate to 0.01.

Ibuprofen for each of the 4 brands
magnetic stirrers
tap water
300 ml glass beakers
Celsius thermometer
   pair of heat resistant gloves
thick lab apron
1 set 


1. Measure 250ml of tap water

2. Pour 250ml of water into a microwave safe container 

3. Heat water in microwave to 37∞ Celsius
4. Pour heated water into 300 ml glass beaker (Only up to the 250 mark though)

5. Put onto magnetic stirrer’s base

6. Drop in magnetic stirring capsule 

7. Turn on magnetic stirrer to high (Let the stirrer get going fast before you drop in the pill)

8. Drop in first brand of Ibuprofen pill

9. Immediately Start stopwatch

10. When the pill dissolves (disappears) stop the stop watch then the stirrer

11. Record the dissolution time of the pill in minutes and seconds

12. Repeat steps 1-11 for the other pills of this same brand (5 more times)

13. Repeat steps 1-12 using the next brand of pills

14. Repeat steps 1-13 with the remaining brands 

15. Average the dissolution rate for each brand.

16. Compare brands


The original purpose of this experiment was to determine the Dissolution rate of different brands of Ibuprofen.

The results of the experiment were that the brand Advil had the fastest dissolution rate.


My hypothesis was that the smallest and smoothest pill would dissolve the quickest because it is the smallest.

The results indicate that this hypothesis should be accepted.

Because of the results of this experiment, I wonder if I compared the rate of dissolution of lactase pills and Advil pills and see which one would dissolve the quickest.

If I were to conduct this project again I would try seeing if different temperatures of water had any effect on the dissolution rate.

Researched by --- Baylee B


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